A charge reversal nano-assembly prevents hepatic steatosis by resolving inflammation and improving lipid metabolism

A charge reversal nano-assembly prevents hepatic steatosis by resolving inflammation and improving lipid metabolism

Blog Article

Lipid metabolism imbalance combined with over-activated inflammation are two key factors for hepatic stestosis.However, on-demand anchoring inflammation and lipid metabolism disorder for hepatic stestosis treatment has yet to be realized.Here Ni-MH/Ni-Cd we propose a charge reversal fullerene based nano-assembly to migrate hepatic steatosis via inhibiting macrophage-mediated inflammation and normalizing hepatocellular lipid metabolism in obesity mice.

Our nano-assembly (abbreviated as FPPD) is comprised of electropositive polyetherimide (PEI), charge-shielded dimethylmaleic anhydride (DMA), and poly(lactic-co-glycolic acid) (PLGA), which provides hydrophobic chains for self-assembly with anti-oxidative dicarboxy fullerene poly(ethylene glycol) molecule (FP).The obtained FPPD nano-assembly owns a charge reversal ability that switches to a positive charge in an acidic environment that targets the electronegative mitochondria both in pro-inflammatory macrophages and steatosis hepatocytes.We demonstrate that the anti-oxidative and mitochondria-targeting FPPD notably reduces inflammation in macrophages and lipid accumulation Neff D89D55N1GB Series 3 Curved 90cm Chimney Hood in Stainless steel in hepatocytes by quenching excessive reactive oxygen species (ROS) and improving mitochondrial function in vitro.

Importantly, FPPD nano-assembly reveals a superior anti-hepatic steatosis effect via migrating inflammation and facilitating lipid transport in obesity mice.Overall, the charge reversal nano-assembly reduces over-activated inflammation and promotes lipid metabolism that provides an effectiveness of a multi-target strategy for hepatic steatosis treatment.